[Lyric] Necrosis (Pillars of Cacophony)

Cells suffer necrosis
When exposed to extreme environmental stimuli
Adverse and excessive
When deleterious mutations encoded in the DNA
Result in ultra-structural and morphological features
Accompanied by extensive swelling of the cell
That contrasts sharply those
Undergoing apoptosis

Terminal
Irreversible
Absolute
The fate is sealed

A passive process not requiring synthesis
Minimal energy requirements
Not regulated by any homeostatic mechanism

The dominant concept
That has permeated
Stipulated that necrosis
Is merely the chaotic breakdown
Of a cell under intolerable conditions
Terminal
Irreversible
Absolute
The fate is sealed

Once triggered, it is inevitable

First, intracellular calcium increases
Next, calpains become activated
Finally, death